Package insert instructions must be followed accordingly. Amikacin should not be physically premixed with other drugs but should be administered separately according to the recommended dose and route. Syringes should be dropped into the container needle end. Amikacin sulphate injection may be given intramuscularly or intravenously. Amikacin pharmacokineticpharmacodynamic pkpd analysis in. Mims, mircomedex, and the australian injectable drugs handbook. Amikacin sulfate injection is indicated in the shortterm treatment of serious infections due to susceptible strains of gramnegative bacteria, including pseudomonas species, escherichia coli, species of indolepositive and indolenegative proteus, providencia species, klebsiellaenterobacterserratia species, and acinetobacter mimaherellea species. Reorder the syringes each month when you refill the amikacin. Reference is also made to the complete response letter issued by this office on july 23, 2014, and to your amendments dated may 15, july 1, november, and november 16, 2015. Amikacin is a semisynthetic aminoglycoside antibiotic derived from kanamycin. Fill in one box to get results in the other box by clicking calculate button. If a daily dose of arikayce is missed, administer the next dose the next day.
Amikacin dosing, indications, interactions, adverse. Dec 02, 2019 amikacin is injected into a muscle, or into a vein through an iv. Broad spectrum antibiotic amikacin sulfate injection, usp. Nov 09, 2018 amikacin is an antibiotic that fights bacteria. The amikacin sulfate injection is indicated in the shortterm treatment of serious bacterial infections due to susceptible strains of gramnegative bacteria, including pseudomonas species, escherichia coli, species of indolepositive and indolenegative proteus, providencia species, klebsiellaenterobacterserratia species, as well as acinetobacter mimaherellea species. Best drug treatment for multidrugresistant and extensively drugresistant tuberculosis pdf. In vitro pharmacodynamic model the pubmed search identified 10 studies in which in vitro timekill curve data of amikacin against pseudomonas aeruginosa were available. Amikacin sulfate injection, usp equivalent to amikacin 1 gram4 ml 250 mgml 4 ml single dose vial for im or iv use manufactured by sicor 9lot 07a122 r x only exp 0109 1. Arikayce also known as liposomal amikacin for inhalation, or lai is an approved treatment for adults developed by insmed to treat lung infections caused by mycobacterium avium complex mac, a type of nontuberculous mycobacteria ntm, which have not responded to standard treatments.
Amikacin sulphate is an aminoglycoside antibiotic with activity against a broad spectrum of gramnegative organisms such as pseudomonas species, escherichia coli, klebsiellaenterobacterserratia and salmonella species author. If respiratory symptoms develop, move victim away from source of exposure and into fresh air. Amikacin is an antibiotic used for a number of bacterial infections. Similar to other aminoglycosides, it works by inhibiting bacterial protein synthesis through irreversible binding to the 30 s ribosomal subunit of susceptible bacteria. Amikacin sulfate, vanillin, spectrometric, pakistan. Amikacin is injected into a muscle, or into a vein through an iv.
This medication is given by injection into a vein or muscle as directed by your doctor. Amikacin hydrate aminoglycoside antibiotic sigmaaldrich. Aminocaproic acid injection, usp, for intravenous administration, is a sterile pyrogenfree solution containing 250 mgml of aminocaproic acid with benzyl alcohol 0. Amikacin pharmacokineticpharmacodynamic analysis in.
Find out what health conditions may be a health risk when taken with amikacin injection. To determine the amikacin sulfate by developing a new spectro photometric method by. This is a guideline only, for more detailed inform ation please refer to. Amikacin is rapidly absorbed after intramuscular administration. Use a clean syringe each time you enter an amikacin vial. The length of your treatment depends on the type of infection you have. One excluded study was an in vivo experiment, and the other study had a design quite different from the others. Eight studies were included in the development of the in vitro pd model after excluding 2 studies 5, 18, 24. Important headings, with respect to its pharmacology, along with a note on important dosage regimen. If victim is not breathing, clear airway and immediately begin artificial respiration. Amikacin is used for short term treatment of serious infections caused by microorganisms that are resistant to other. See actual entry in rtecs for complete information.
Pdf quantitative determination of amikacin sulfate using vanillin. Jan 08, 2020 arikayce also known as liposomal amikacin for inhalation, or lai is an approved treatment for adults developed by insmed to treat lung infections caused by mycobacterium avium complex mac, a type of nontuberculous mycobacteria ntm, which have not responded to standard treatments. Serum concentrations of amikacin should be monitored when feasible to assure adequate levels and to avoid potentially toxic levels and prolonged peak concentrations above 35 micrograms per ml. Dosage of amikacin sulfate is expressed in terms of amikacin and calculated on a. Product code search allows you to enter the product code into the field ref, the lot number in the field lot, and the revision information in the third box if. The amikacin manufacturing companies in india are offering best products at low prices. Amikacin sulfate amikin discontinued is an antibiotic injection prescribed to treat bacterial meningitis, infected burns, cystic fibrosis, and severe uti infections. The use of amikacin for firstline therapy is limited, despite its excellent bactericidal activity against gramnegative organisms. Amikacin sulfate amikacin sulfate dose, indications. Amikacin sulfate injection, usp sagent pharmaceuticals. It is used either by injection into a vein or muscle. This word document deals with the drug profile of amikacin.
Quantitative determination of amikacin sulfate using vanillin from. In normal adult volunteers, average peak serum concentrations of about 12, 16, and 21 mcgml are obtained 1 hour after intramuscular administration of 250 mg 3. Do not selfinject this medicine if you do not understand how to give the injection and properly dispose of used needles, iv tubing, and other items used to inject the medicine. Learn more about the word amikacin, its origin, alternative forms, and usage from wiktionary. Pharmacokinetics and urinary excretion of amikacin in low. Information and translations of amikacin in the most comprehensive dictionary definitions resource on. The measurements obtained are used in the diagnosis and treatment of amikacin overdose and in monitoring levels of amikacin to ensure appropriate therapy.
Act, for amikacin sulfate injection usp, 50 mgml 100 mg2 ml vial. Needlessyringes should be disposed of by placing them in a sharps container. In the ifu tab you can either use the product code search or the keyword search. Careful recordkeeping of prescribing information, including quantity, frequency, and renewal requests, as required by state and federal law, is strongly advised. The catalog displays all strengths and sizes along with the description, imprint code, ndc and photo for each product. Amikacin is used to treat severe or serious bacterial infections. Data should be separated in coma, space, tab, or in separated lines. Amikacin is actively transported into the bacterial cell where it binds to. Amikacin unit conversion amikacin unit conversion in batch note. Amikacin should not be physically premixed with other drugs, but should be administered separately according to the recommended dose and route. Amikacin sulphate is an aminoglycoside antibiotic with. Amikacin sulfate injection, usp is a semisynthetic aminoglycoside antibiotic derived from kanamycin.
It may be supplied in packs containing 5 x 500 mg2 ml vials marketing authorisation holder and manufacturer responsible for batch release in europe. Amikacin liposome inhalation suspension for treatmentrefractory lung disease caused by mycobacterium avium complex convert. Intended use the qms amikacin assay is intended for the quantitative determination of amikacin in human serum or plasma on automated clinical chemistry analyzers. Only select registry of toxic effects of chemical substances rtecs data is presented here. To determine the amikacin sulfate by developing a new.
Poor oral absorption, a short halflife, and serious renal, auditory, and vestibular toxicities necessitate frequent intravenous administration, with concomitant monitoring of drug levels to ensure that the levels in plasma remain within a narrow therapeutic. Inhaled amikacin the toronto adult cystic fibrosis. Amikacin intended use the tdxtdxflx amikacin assay is a reagent system for the quantitative measurement of amikacin, an aminoglycoside antibiotic drug, in serum or plasma. Information and translations of amikacin in the most comprehensive dictionary definitions resource on the web. Amikacin investigated as a drug, natural product, and reproductive effector. Take your amikacin at approximately the same time everyday so that it is easier to remember. The patients pretreatment bodyweight should be obtained for calculation of correct dosage. Amikacin may also be used for purposes not listed in this medication guide. Amikacin sulfate injection, usp safety data sheet sds may, 2016 sds no sds 077 sds version no 1. Amikacin injection comes as a liquid to be injected intravenously into a vein or intramuscularly into a muscle every 8 or 12 hours two or three times a day. Get here the entire database of amikacin manufacturers, amikacin injection suppliers, exporters from india. The product catalog provides you with a full listing of tevas brand and generic product lines. Pdf standard multiple and single daily dosing of amikacin in. Amikacin belongs to a class of medications called aminoglycoside antibiotics.
Amikacin definition, a widespectrum semisynthetic antibiotic, c22h45n5o, used in the treatment of infections, especially those caused by susceptible gramnegative bacilli. It is also used for the treatment of multidrugresistant tuberculosis. Fda grants qidp designation to bayers amikacin inhale and ciprofloxacin dry powder for inhalation. Urine should be examined for decreased specific gravity, increased excretion of proteins, and the presence of cells or casts. Amikacin 674786gmgasamikacinbase 39831555 sigmaaldrich. Percocetoxycodone and acetaminophen tablets, uspcii rx. Crcl 90 mlmin and aged amikacin injection is a clear, colourless to pale yellow solution for injection which comes in glass containers called vials. Amikacin injection manufacturers, suppliers and exporters.
In patients with impaired renal function, either the dose or the dosage interval. Amikacin medical definition merriamwebster medical. Amikacin is a prescription drug used to treat certain serious infections that are caused by bacteria such as meningitis infection of the membranes that surround the brain and spinal cord and infections of the blood, abdomen stomach area, lungs, skin, bones, joints, and urinary tract. It acts by inhibiting protein synthesis of susceptible bacteria. Dec 06, 2019 aminocaproic acid injection, usp, for intravenous administration, is a sterile pyrogenfree solution containing 250 mgml of aminocaproic acid with benzyl alcohol 0. Amikacin deluje putem vezivanja za bakterijsku 30s ribozomalnu podjedinicu, cime uzrokuje pogresno ocitavanje irnk te time onemogucava bakterijsku sintezu proteina koji su vitalni za njen rast medicinske upotrebe. Amikacin definition of amikacin by medical dictionary. Also take the doses as close to 12 hours apart as possible. Store in accordance with information listed on the product insert. The contents of the arikayce vial can then be poured into the medication reservoir of the nebulizer handset. Amikacin sulphate 500 mg injection is used to treat a variety of bacterial infections of the lungs, skin, abdomen, and blood caused by li, streptococci.
Amikacin photo key points amikacin is an aminoglycoside antibiotic that inhibits bacterial growth in susceptible organisms by interfering with bacterial protein synthesis binds to 30s and 50s ribosomal subunits, resulting in a defective bacterial cell membrane exhibit concentrationdependent bacterial killing higher peak levels means more bacterial killing has activity against many. This includes joint infections, intraabdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. To prepare and take amikacin, please also refer to preparing your treatment and taking your treatment. Manufacturing cmcmicrobiologyprocessing label is not available on this site. Arikayce consists of liposomes that contain amikacin, an antibiotic used to treat severe or serious bacterial. When amikacin is injected intravenously, it is usually infused injected slowly over a period of 30 to 60 minutes. It is usually given every 8 hours or as directed by your doctor. Amikacin injection is used to treat susceptible gramnegative bacterial infections. In people with kidney failure, dosage must be adjusted according to the creatinine clearance, usually by reducing the dosing. Webmd provides common contraindications for amikacin injection.
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